CustomBone Service (CBS) is a custom-made cranial implant made of hydroxyapatite (HA), a Ca/P-derivative with chemico-physical features and a 3D porous structure which resembles the mineral component and structure of human bone. Compared to other alloplastic alternatives on the market (i.e. PMMA, PEEK, Titanium), these peculiar properties makeCustomBone Service the ideal candidate for replacing cranial bone defect in a physiological manner.